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CENTER for Mitochondrial Imaging Research and Diagnostics

MISSION

innovate, create, and use advanced technologies
in a programmatic context
to study mitochondria in health and disease.
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Why mitochondria

For a long time, we thought
mitochondria were just the powerhouses of the cell.

This has never been true.
 
Mitochondria are the most interactive organelles in the eukaryotic cell. With only 1.4% of the human genome controlling their function, mitochondria have the striking capability to govern a multitude of cellular functions, from metabolism and ion homeostasis to cell fate and immunity.  
 
At MitoCare, our team pairs advanced, high-resolution 3D imaging modalities in vitro
and in vivo with other cutting-edge technologies to study mitochondrial health and disease pathogenesis, diagnostics, and potential therapeutic targets.
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New Publication!

Adaptation of the heart to Frataxin depletion: Evidence that integrated stress response can predominate over mTORC1 activation

Vásquez-Trincado C, Patel M, Sivaramakrishnan A, Bekeová C, Anderson-Pullinger L, Wang N, Tang HY, Seifert EL
Human Molecular Genetics, September 2021

The findings described in this manuscript suggest that the FXN depleted heart can suppress a major ATP demanding process such as protein translation, which, together with some preservation of β-oxidation, could be adaptive, at least in the short term.

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