CENTER for Mitochondrial Imaging Research and Diagnostics
innovate, create, and use advanced technologies
in a programmatic context
to study mitochondria in health and disease.
For a long time, we thought
mitochondria were just the powerhouses of the cell.
This has never been true.
Mitochondria are the most interactive organelles in the eukaryotic cell. With only 1.4% of the human genome controlling their function, mitochondria have the striking capability to govern a multitude of cellular functions, from metabolism and ion homeostasis to cell fate and immunity.
At MitoCare, our team pairs advanced, high-resolution 3D imaging modalities in vitro and in vivo with other cutting-edge technologies to study mitochondrial health and disease pathogenesis, diagnostics, and potential therapeutic targets.
Adaptation of the heart to Frataxin depletion: Evidence that integrated stress response can predominate over mTORC1 activation
Vásquez-Trincado C, Patel M, Sivaramakrishnan A, Bekeová C, Anderson-Pullinger L, Wang N, Tang HY, Seifert EL
Human Molecular Genetics, September 2021
The findings described in this manuscript suggest that the FXN depleted heart can suppress a major ATP demanding process such as protein translation, which, together with some preservation of β-oxidation, could be adaptive, at least in the short term.